Mammalian Retroelements
نویسندگان
چکیده
منابع مشابه
Mammalian retroelements.
The eukaryotic genome has undergone a series of epidemics of amplification of mobile elements that have resulted in most eukaryotic genomes containing much more of this 'junk' DNA than actual coding DNA. The majority of these elements utilize an RNA intermediate and are termed retroelements. Most of these retroelements appear to amplify in evolutionary waves that insert in the genome and then g...
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Advances in the science of toxicogenomics have opened the door to major advances in our understanding of the molecular basis of environmental pathogenesis and the role of environmental factors in human disease. This report summarizes major findings in the laboratory defining the molecular basis of L1 retroelement activation in mammalian cells and the architecture of gene regulatory networks inv...
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ANTHROPOLOGY. For the article ‘‘Ancient mitochondrial M haplogroups identified in the Southwest Pacific,’’ by D. Andrew Merriwether, Jason A. Hodgson, Françoise R. Friedlaender, Robin Allaby, Salvatore Cerchio, George Koki, and Jonathan S. Friedlaender, which appeared in issue 37, September 13, 2005, of Proc. Natl. Acad. Sci. USA (102, 13034–13039; first published September 6, 2005; 10.1073 pna...
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Two well-known retroelements, L1 and Alu, comprise about one third of the human genome and are nearly equally distributed between the intergenic and intragenic regions. They carry different regulatory elements and contribute structurally and functionally to the expression of our genes. Recent data also suggest that hundreds of intronic L1s and Alus interfere with the transcription of human gene...
متن کاملA Tetrahymena thermophila ribozyme-based indicator gene to detect transposition of marked retroelements in mammalian cells.
We devised an indicator gene for retrotransposition based on an autocatalytic ribozyme element--the Tetrahymena thermophila 23S rRNA group I intron--which can self-splice in vitro and does not require--at variance with nuclear mRNA introns--any specific pathway and cellular component for the completion of the splicing process. Several constructs, with the Tetrahymena intron adequately modified ...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2002
ISSN: 1088-9051
DOI: 10.1101/gr.282402